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The main properties of PHAsPolyhydroxyalkanoates (PHA) or the polyhydroxy fatty acids, are a family of biodegradable polyesters. As in many mammals, including humans, that hold … More make them a great candidate for biomedicine applications – PHAsPolyhydroxyalkanoates (PHA) or the polyhydroxy fatty acids, are a family of biodegradable polyesters. As in many mammals, including humans, that hold … More are fully biodegradable, biocompatibleBiocompatibility is a general term describing the property of a material being compatible with living tissue. Biocompatible materials do not produce a… and non-toxic.
PHAsPolyhydroxyalkanoates (PHA) or the polyhydroxy fatty acids, are a family of biodegradable polyesters. As in many mammals, including humans, that hold … More are tested as drug carriersA drug carrier is any substrate used in the process of drug delivery which serves to improve the selectivity, effectiveness, and/or safety of drug adm… – in dental medicine, for targeted application of active agents, and for drugs with slow or controlled release.
PHAsPolyhydroxyalkanoates (PHA) or the polyhydroxy fatty acids, are a family of biodegradable polyesters. As in many mammals, including humans, that hold … More might help fight with antibiotic resistanceAntibiotic resistance happens when germs like bacteria and fungi develop the ability to defeat the drugs designed to kill them. That means the germs a… problem.1, 7
PHAsPolyhydroxyalkanoates (PHA) or the polyhydroxy fatty acids, are a family of biodegradable polyesters. As in many mammals, including humans, that hold … More are a promising material for tissue engineering – for joint implants, medical devices and tissue reconstruction.6
Tissue engineering seeks for materials and ways how to shape it to build the most favorable environment for cell cultures. This scaffold for cell proliferation must be biocompatibleBiocompatibility is a general term describing the property of a material being compatible with living tissue. Biocompatible materials do not produce a… and supportive for growth, migration, and differentiation of cells. Optionally biodegradability of the scaffold is required.
Tissue engineering uses both 2D structures (films) and 3D structures like foams, sponges, hydrogels or nanofibers. Biopolymers like PHAsPolyhydroxyalkanoates (PHA) or the polyhydroxy fatty acids, are a family of biodegradable polyesters. As in many mammals, including humans, that hold … More are suitable for nanofiber production by electrospinningThe electrospinning method allows the preparation of very fine fibers ranging from um to nm from a polymer solution or a polymer melt using electrosta… More. Nanofibers well mimic extracellular matrixThe extracellular matrix is the name for the structure that fills the space between cells in an organism. It is made up of a network that consists mai… More.
We are developing sustainableAn attempt to provide the best outcomes for the human and natural environments both now and into the indefinite future. One famous definition of susta… More and safe nanofibrous wound dressings based on Hydal PHAPolyhydroxyalkanoates (PHA) or the polyhydroxy fatty acids, are a family of biodegradable polyesters. As in many mammals, including humans, that hold … More. Wound dressings are needed whenever the skin is injured – from acute traumas like burns, chirurgic wounds to chronic wounds and ulcers. By electrospinning process, we can form PHAsPolyhydroxyalkanoates (PHA) or the polyhydroxy fatty acids, are a family of biodegradable polyesters. As in many mammals, including humans, that hold … More nanofibers – biocompatibleBiocompatibility is a general term describing the property of a material being compatible with living tissue. Biocompatible materials do not produce a… and biodegradableBiodegradation is the breakdown of organic matter by microorganisms, such as bacteria and fungi. scaffold for skin regeneration.
New materials bring benefits not only to people, but also to the whole nature. Wound dressings are highly specific products, which cannot be reused or recycled. Thus, bio-based and biodegradableBiodegradation is the breakdown of organic matter by microorganisms, such as bacteria and fungi. polymers are the most suitable materials for these single-use products considering the environmental footprint.
Millions of people with chronic or acute skin wounds need high-quality health care, however billions of people and much more plants and animals need healthy planet – clean drinking water, low atmospheric CO2 levels, stable climate, fertile soil…
Infections that accompany chronic wounds are treated by antibiotics. However, long-term application of antibiotics can lead to antibiotic resistanceAntibiotic resistance happens when germs like bacteria and fungi develop the ability to defeat the drugs designed to kill them. That means the germs a… development and incurable infection. It becomes a big problem not only for one patient, but resistant pathogens can easily infect others and spread through the population.
We search how to prevent infection by natural ingredients like essential oils and honey. P3HBPolyhydroxy butyrate (PHB) is a Polyhydroxyalkanoates (PHA), a polymer belonging to the polyesters class that are o… More itself also has moderate antimicrobial properties.1 These formulations cannot replace highly effective antibiotics, but can prevent infection burden and reduce the need for antibiotics.
Prevention and early and effective treatment of chronic wounds helps to sustain patient’s quality of life and to prevent global issues like plastic pollution, CO2 emission and antibiotics resistance.
1 Ma, L., Z. Zhang, J. Li, et al. A New Antimicrobial Agent: Poly (3-hydroxybutyric acid) Oligomer. Macromolecular Bioscience. 2019, 19(5): 1800432. doi: 10.1002/mabi.201800432.
2 Peschel, G., H.-M. Dahse, A. Konrad, et al. Growth of keratinocytes on porous films of poly(3-hydroxybutyrate) and poly(4-hydroxybutyrate) blended with hyaluronic acid and chitosan. Journal of Biomedical Materials Research Part A. 2008, 85A(4): 1072-1081. doi: 10.1002/jbm.a.31666.
3 Saito, T., K. Tomita, K. Juni and K. Ooba. In vivo and in vitro degradation of poly(3-hydroxybutyrate) in rat. Biomaterials. 1991, 12(3): 309-12. doi: 10.1016/0142-9612(91)90039-d.
4 Gogolewski, S., M. Jovanovic, S. M. Perren, et al. Tissue response and in vivo degradation of selected polyhydroxyacids: polylactides (PLAPolylactide or Polylactic Acid (PLA), a biodegradable, thermoplastic, linear aliphatic polyester based on lactic acid, a natural acid, is mainly produ… More), poly(3-hydroxybutyrate) (PHBPolyhydroxy butyrate (PHB) is a Polyhydroxyalkanoates (PHA), a polymer belonging to the polyesters class that are o… More), and poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBPolyhydroxy butyrate (PHB) is a Polyhydroxyalkanoates (PHA), a polymer belonging to the polyesters class that are o… More/VA). J Biomed Mater Res. 1993, 27(9): 1135-48. doi: 10.1002/jbm.820270904.
5 Bhatia, S. K., P. Wadhwa, R. K. Bhatia, et al. Strategy for Biosynthesis of Polyhydroxyalkonates Polymers/Copolymers and Their Application in Drug Delivery. In: V. C. Kalia. Biotechnological Applications of Polyhydroxyalkanoates. Singapore: Springer Singapore, 2019: 13-34. 978-981-13-3759-8.
6 Kalia, V. C., S. Ray, S. K. S. Patel, et al. The Dawn of Novel Biotechnological Applications of Polyhydroxyalkanoates. In: V. C. Kalia. Biotechnological Applications of Polyhydroxyalkanoates. Singapore: Springer Singapore, 2019: 1-11. 978-981-13-3759-8.
7 Giourieva, V. S., R. M. Papi and A. A. Pantazaki. Polyhydroxyalkanoates Applications in Antimicrobial Agents Delivery and Wound Healing. In: V. C. Kalia. Biotechnological Applications of Polyhydroxyalkanoates. Singapore: Springer Singapore, 2019: 49-76. 978-981-13-3759-8.
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